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MTV's The Real World star Karamo Brown took a few years out of the limelight, but he's now back with three TV series, a movie, and a very important new mission. His new organization, 6in10, is meant to battle the stigma and miseducation around black gay and bi men and HIV transmission. Now that the stats are closer to one in two black gay or bi men will become HIV-positive in their lifetimes, Brown's mission is all the more urgent. Plus: Inside the life-saving new operations that are letting people with HIV get new kidneys after their own have failed. Also in this issue: Fighting drug resistance, a mumps outbreak in L.A., a new hep C cure, and Truvada goes generic.

Former basketball star DeMarco Majors talks about surviving assault and living with HIV.

Our much-anticipated Annual  HIV & Hep C Treatment Guide profiles every medication used to treat HIV, hep C, or related complications. Get the low down on what your meds do, which side effects to watch out for, and what you should never take them with. Plus: Basketball star to TV star, DeMarco Majors talks about learning he was HIV-positive, the impact on his treatment, and what demons he still struggles with.

He mesmerized us as Omar on The Wire, charmed us as Chalky on Boardwalk Empire, and still has us coming back for more as half of the titular Hap and Leonard. So expertly crafting another gay character on TV (real-life, HIV-positive veteran Ken Jones on When We Rise) was smooth sailing for the actor and activist. But the reasons why he took this role was way more personal than many realize.

This "Just Diagnosed" issue looks at the key things you need to know when you first find out you're living with HIV. There's 10 tips to coping with the new diagnosis, 7 ways to stay safe, and how treatment and disclosure is changing in Jackson, Mississippi, and San Francisco. Plus: Michael K. Williams (the star of When We Rise and Hap and Leonard) talks about why playing a gay, HIV-positive man was so personal for him. Cecilia Chung, one of the most visible transgender, HIV+ leaders in U.S. meets her onscreen counterpart and Twiggy Pucci Garcon takes us inside the Kiki scene — and its HIV advocacy work, one LGBT youth at a time.

He’s the most decorated diver in Olympic history, has been HIV-positive nearly 30 years, and has battled addiction, homophobia, depression, and bad boyfriends. 

Olympic gold medalist Greg Louganis is just one of the many long-term thrivers— from grandmothers to veterans — that we talk to for our special HIV and aging feature, including  pop star Sia's powerhouse manager, David Russell,  who tells us about being poz in the music industry and more.