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Imparied Immunity Is Linked With Treatment Delay

Imparied Immunity Is Linked With Treatment Delay


HIVers who start therapy when they have severe immune system damage may end up with incomplete immune recovery, according to a study in the December 15 edition of Journal of Infectious Diseases. A total of 199 HIV-positive people who began HAART with CD4 counts below 50 were studied to determine their reactions to antigen tests and vaccines. More than 80% of the study subjects had negative responses to candida and mumps antigens. Eighty-six percent of the study participants had an impaired response to a tetanus vaccine, and 54% responded poorly to hepatitis A inoculations. Researchers determined, however, that an incomplete recovery did not translate into a heightened risk for AIDS-related opportunistic infections.

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