Taking Three Nukes? You Can Do Better

HIVers taking a three-nucleoside regimen that includes Ziagen should switch to a more potent combination even if they currently have undetectable viral levels, researchers reported in The Journal of Infectious Diseases. They say a study of 744 HIVers has shown patients on a Ziagen-based nucleoside regimen had an 85% greater risk of eventual viral rebound than those taking Sustiva plus two nukes. Blood-fat levels also were higher among Ziagen users.