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Combination Drugs



Generic names: ombitasvir, paritaprevir, and ritonavir



What it does:
Treats chronic hepatitis C

Traditional dosage:
Two tablets taken orally, once daily with food; used commonly with ribavirin (Copegus, Virazole, Ribasphere). (Technivie is a combo of a NS5A Inhibitor, a NS3/4A Protease Inhibitor, and a CYP3A Inhibitor.)

Drug interactions, precautions, & recommendations:
Do not take if you have cirrhosis; nor in combination with Colchicine, Alfuzosin HCI, Carbamazepine, phenytoin, phenobarbital, Rifampin, or ergot derivatives. Discontinue medications with ethinyl estradiol (estrogen) prior to starting. If taken with ribavirin (Copegus, Rebetol), all ribavirin warnings and contraindications apply.

The Federal Drug Administration issued the following label warning to be added to all hepatitis C (HCV) direct-acting antivirals (DAAs): Risk of hepatitis B virus (HBV) reactivation in patients connected with HCV and HBV has been reported, in some cases resulting in fulminant hepatitis, hepatic failure, and death.

Side effects:
Most serious: liver failure
Other: asthenia, fatigue, nausea, insomnia

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