Meth + Protease Drugs = Danger

Combining protease inhibitors with crystal meth can lead to meth overdoses. Protease drugs and meth are broken down by the same liver enzyme, researchers explain, but the enzyme works first on the anti-HIV medications. This allows meth to build up in the bloodstream to levels three to 10 times higher than if it were broken down immediately, which can lead to a potentially fatal overdose. The risks are especially high, researchers warn, with Norvir and Rescriptor.