Traditional dosage: For individuals weighing 132 pounds or more, 40 mg, in capsules or oral solution, twice daily; for patients weighing less than 132 pounds, 30 mg twice daily.
Drug interactions, precautions, & recommendations: Do not take with zidovudine-containing drugs (Retrovir, Combivir Trizivir). Do not take with hydroxyurea (Droxia, Hydrea). Use caution with Videx EC, Adriamycin, Rubex, Copegus, Rebetol, Ribasphere, Virazole, Roferon-A, and Intron-A. Use caution if you have liver, pancreas, or kidney problems; peripheral neuropathy; or gallstones. Dosing adjustments may be needed if you have renal impairment or are undergoing hemodialysis. Do not drink alcohol while on the drug.
Side effects: Most serious: buildup of lactic acid in blood, serious liver problems, pancreatitis, changes in immune system or body fat, peripheral neuropathy Other: headache, diarrhea, rash, nausea, vomiting