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Protease Inhibitors



Generic name: darunavir



What it does:
Helps prevent replication of HIV

Traditional dosage: One 800 mg tablet with one 100 mg Norvir capsule, once daily, with food; or one 600 mg tablet with one 100 mg Norvir tablet or capsule taken twice daily, with food for those with drug resistance.

Drug interactions, precautions, & recommendations: Do not take with Uroxatral, D.H.E. 45, Migranal, Cafergot, Ergomar, methylergonovine, Propulsid, Orap, oral midazolam, Halcion, St. John’s Wort, Mevacor, Altoprev, Advicor, Zocor, Simcor, Vytorin, Rifadin, Rifater, Rifamate, Rimactane, Revatio (when used to treat pulmonary arterial hypertension), Crixivan, Kaletra, Invirase, Eliquis, Pradaxa, Xarelto, Vfend, Priftin, dexamethasone, Olysio, Afinator, Serevent, Stendra, or Incivek. Colchicine (Colycris, Mitigare) is contraindicated in patients with liver or kidney problems. Use caution if taking Viagra, Revatio, Levitra, Staxyn, Cialis, Adcirca, Lipitor, Crestor, Pravachol, Seroquel, Col-Probenecid, Coartem, or Riamet. May reduce birth control pills’s efficacy; take other precautions.

Side effects:
Most serious: severe liver disease, severe rash or pustules, high blood sugar or diabetes, changes in body fat or immune system

Other: diarrhea, nausea, mild rash, headache, stomach pain, vomiting

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