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Protease Inhibitors



Generic Name: tipranavir


Boehringer Ingelheim

What it does:
Helps prevent replication of HIV

Traditional dosage:
500 mg (two 250 mg capsules or 5 ml of oral solution) with 200 mg (two 100 mg capsules/tablets or 2.5 ml of solution) of Norvir, twice daily. If taken with Norvir capsules or solution, may be taken with or without meals; if taken with Norvir tablets, must be taken with meals.

Drug interactions, precautions, & recommendations:
For treatment-experienced patients, in combination with at least two other anti-HIV drugs. Do not use with other protease inhibitors. Do not take with Rifadin, ergot derivatives (Dihydroergotamine, ergonovine, ergotamine, methylergonovine), St. John’s Wort, Versed, Latuda, Cisapride, Revatio, Uroxatral, Altoprev, Mevacor, Orap, Zocor, Halcion, or certain anti-arrhythmic drugs (Amiodarone, bepridil, flecainide, propafenone, quinidine). If taking birth control pills, switch to another method of contraception. Use with caution with Flonase, Viagra, Cialis, Levitra, or Seroquel; or if taking certain anti-seizure medications. Use with caution if you have hemophilia or other conditions that increase the chance of bleeding; or liver disorders.

Side effects:
Most serious: evere or fatal liver disease, severe bleeding in the brain, new or worsened diabetes and hyperglycemia
Other: diarrhea, nausea, fever, vomiting, tiredness, headache, stomach pain, rash, increased sun sensitivity, increased blood fat (lipid) levels, changes in body fat

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