Traditional dosage: 600 mg (six 100 mg tablets), twice daily, with a meal. Swallow tablets whole with water; do not chew, break, or crush. Also available in capsules or oral solution. Reduced dosage recommended for people taking other protease inhibitors.
Drug interactions, precautions, & recommendations: Do not take with Xatral, Cordarone, Tambocor, Vascor, Rythmol, Fucidin, Hismanal, Seldane, Orap, Propulsid, Cafergot, Migranal, D.H.E. 45, Ergotrate, Maleate, Vfend, Mevacor, Zocor, Halcion, Versed, Advair, Serevent, Levitra, Revatio (if used for pulmonary arterial hypertension), St. John’s Wort. Do not take with both Invirase and any version of rifampin (Rimactane, Rifadin, Rifater, or Rifamate), and use with caution with either drug separately. Use with caution with Seroquel, Olysio, Lipitor, Crestor, Viagra, Levitra, Cialis, Adcirca, Tracleer, Rapamune, Flonase, Crixivan, Viracept, Videx, Mycobutin, Aptivus, Rescriptor, Reyataz, Celsentrin, Telzir, Prezista, Tiazac, Adalat, Isoptin, Nizoral, Sporanox, Demerol, Tegretol, Dilantin, phenobarbital, Mycobutin, Biaxin, Duragesic, theophylline, Colcrys (used for treatment of gout), certain anticancer medications, certain antidepressants. Use with caution if you have other liver problems or diabetes.
Side effects: Most serious:
worsening of liver disease, pancreatitis, diabetes or high blood sugar, elevated cholesterol or triglycerides, changes in body fat, increased bleeding among hemophiliacs, severe skin reactions
Other: rash, abdominal pain, diarrhea, feeling weak or tired, headache, nausea, vomiting, changes in taste, loss of appetite, dizziness, tingling feeling or numbness (on hands, feet, or around the lips)