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Generic name: Emtricitabine, rilpivirine, and tenofovir alafenamide


Gilead Sciences

Traditional dosage:
One tablet (200 mg of emtricitabine, 25 mg of rilpivirine, and 25 mg of tenofovir alafenamide), once daily, with a meal . Rilpivirine is an NNRTI, the other components NRTIs. Odefsey is for those new to antiretroviral drugs, who have a viral load of 100,000 copies/ml or less; or can be used as a replacement regimen for individuals with a viral load of 50 copies/ml or less.

Drug interactions, precautions, & recommendations:
Do not take with medicines that contain lamivudine (Epivir, Epivir-HBV, Epzicom, Combivir, Trizivir), other antiretroviral medications, antiseizure or antituberculosis medicine, proton pump inhibitors (Kapidex, Dexilant), adefovir (Hespera), St John’s Wort, or more than one dose of dexamethasone. Use caution when taking antacids, antifungal medications, H2-receptor antagonists, antibiotics, or methadone. If taken with Harvoni, you should be monitored.

Side effects:
Most serious: buildup of lactic acid in blood, severe liver problems, hepatitis B flare-up, depression, changes in immune system
Other: insomnia, headache, rashes, diarrhea, nausea, fatigue, dizziness, depression, abnormal dreams, vomiting, stomach or other pain, weight gain

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