Scroll To Top

A Boost to Fight HIV?

A Boost to Fight HIV?


Animal research shows that altering a key gene that produces the CCR5 protein on the surface of immune system cells'which is a portal through which HIV attaches to and infects the cells'can significantly boost cellular resistance to the virus, according to a study in the journal Nature Biology. The technique uses a harmless virus called a 'zinc-finger nuclease' that binds to a key gene in the CCR5 protein, changing it enough so that HIV is unable to attach to it. HIV-infected mice injected with the zinc-finger nuclease virus exhibited a tenfold reduction in blood-based viral levels and a fivefold increase in the number of circulating T cells. 'What's really exciting is that the change in the genome is permanent, and inherited by all 'daughter' T cells created when the alerted T cells multiply,' said lead researcher Philip Gregory of Sangamo Biosciences told The company plans to begin human studies by the end of the year. If successful, the treatment could offer a long-lasting'perhaps permanent'way to control HIV infection.

Advocate Channel - The Pride StoreOut / Advocate Magazine - Jonathan Groff and Wayne Brady

From our Sponsors

Most Popular

Latest Stories

HIV Plus Editors