
Treatment GuideJust DiagnosedSex & DatingAfrican AmericanStigmaAsk the HIV DocPrEP En EspañolNewsVoicesPrint IssueVideoOut 100
CONTACTCAREER OPPORTUNITIESADVERTISE WITH USPRIVACY POLICYPRIVACY PREFERENCESTERMS OF USELEGAL NOTICE
© 2025 Pride Publishing Inc.
All Rights reserved
All Rights reserved
Scroll To Top
By continuing to use our site, you agree to our Private Policy and Terms of Use.
Even five years after switching to newer medications, HIVers who lost subcutaneous fat as a result of taking first-generation anti-HIV meds still show strikingly less body fat than seronegative individuals, according to a study published in the July 17 issue of the journal AIDS. That lack of fat ' just below the layer of skin ' was marked in HIVers' legs and lower trunk, where body fat is associated with a lower risk of cardiovascular disease ' but less so in the visceral, or deep, fat and upper-body fat associated with increased cardiovascular risk. 'This shows that the damage done by certain antiretroviral drugs, which were lifesaving at the time but reduced body fat, is long-term,' says Carl Grunfeld, MD, Ph.D., who is chief of the metabolism and endocrine sections at the San Francisco Veterans Affairs Medical Center, which conducted the study with the University of California, San Francisco. 'This is the first study to demonstrate that the effect lasts at least five years.' The study authors twice measured total body fat among 477 HIV-infected participants and 214 noninfected control subjects. The first measurement was taken between 2000 and 2002, when most people in the United States with HIV were taking drug combinations that included the fat-toxic drugs stavudine and zidovudine. The second measurement was taken five years after the first, by which time most patients had been switched to modern highly active antiretroviral therapy, which has not been shown to destroy body fat. The researchers found that at both the first and second measurements, the HIVers in the study had significantly less body fat, especially lower body fat, than the control participants. The difference in upper-body fat was much smaller, says Grunfeld: 'The worst initial loss was in the best fat, and the least loss was in the worst fat. Five years later at the second measurement the HIV-infected patients had gained very little lower body fat.' The result, he says, is increased risk of cardiovascular disease among HIVers. There are several reasons for the increased cardiovascular disease risk, explains Grunfeld, who is also a professor of medicine at UCSF. Upper-body fat is known to be associated with elevated insulin resistance and high blood triglycerides ' two known heart disease risk factors ' while lower-body fat is associated with decreased insulin resistance and lower triglycerides. In addition, HAART is known to be associated with increased triglycerides, as is HIV itself. 'It all adds up to bad cardiovascular-disease risk for HIV-infected people,' Grunfeld says. 'Furthermore, it's a risk that is probably not going to go away. Patients and physicians need to be aware of it ' and take whatever other steps they can to reduce that risk.'
From our Sponsors
Most Popular
Lexi Love comes out as HIV+ after Trump deletes federal resources
January 23 2025 11:23 AM
Ricky Martin delivers showstopping performance for 2024 World AIDS Day
December 05 2024 12:08 PM
Trump's orders prompt CDC to erase HIV resources
January 31 2025 5:29 PM
This long-term HIV survivor says testosterone therapy helped save his life.
December 16 2024 8:00 PM
California confirms first case of even more deadly mpox strain
November 18 2024 3:02 PM
Plus: Featured Video
Latest Stories
Grindr is reminding us why jockstraps are so sexy and iconic
May 02 2025 5:36 PM
Broadway's best raise over $1 million for LGBTQ+ and HIV causes
April 03 2025 7:15 PM
Season 4 of The Switch on resilience & radical self-love returns this spring
March 26 2025 12:20 PM
BREAKING NEWS: Trump admin moves to end federal HIV prevention programs
March 18 2025 6:10 PM
A camp for HIV-positive kids is for sale. Here's why its founder is celebrating
January 02 2025 12:21 PM
Decades of progress, uniting to fight HIV/AIDS
December 01 2024 12:30 PM
Climate change is disrupting access to HIV treatment
November 25 2024 11:05 AM
HRC holds 'die-in' to protest Trump health care cuts
April 28 2025 2:11 PM
Two right-wing Supreme Court justices signal they may uphold access to PrEP and more
April 21 2025 4:10 PM
The Talk Season 5 premieres this spring with HIV guidance for the newly diagnosed
March 26 2025 1:00 PM
Jess King is here to help you live your happiest, healthiest life yet
March 24 2025 4:35 PM
Gerald Garth is keeping people of color happy and healthy through trying times
March 11 2025 3:38 PM
Tyler TerMeer vows to continue to fight for health care for all
January 28 2025 3:00 PM
'RuPaul's Drag Race' star Trinity K Bonet quietly comes out trans
December 15 2024 6:27 PM
500,000 Children at Risk: PEPFAR Funding Crisis
April 08 2025 3:51 PM
Discover the power of Wellness in your life
March 26 2025 12:41 PM
Celebrating Black History Month with our annual African American issue
February 01 2025 3:28 PM
Plus nominated for 2025 GLAAD Media Award
January 22 2025 12:42 PM
AIDS Memorial Quilt displayed at White House for the first time
December 02 2024 1:21 PM
Hollywood must do better on HIV representation
December 01 2024 9:00 AM