Traditional dosage: One tablet (300 mg atazanavir and 150 mg cobicistat) once daily with food, in combination with other antiretroviral drugs. Atazanavir (Reyataz) is a protease inhibitor and cobicistat (Tybost) a boosting agent.
Drug interactions, precautions, & recommendations: Do not take with protease inhibitors, roxatral, Propulsid, Propulsid Quicksolv, Mitigare, Colcrys, Multaq, D.H.E. 45, Embolex, Migranal, Cafergot, Migergot, Ergomar, Ergostat, Medihaler, Wigraine, Wigrettes, Ergotrate, Methergine, Crixivan, Camptosar, Advicor, Altoprev, Mevacor, Latuda, Versed, Viramune, Viramune XR, Orap, Ranexa, Rimactane, Rifadin, Rifater, Rifamate, Revatio (when used for lung problems), Zocor, Vytorin, Simcor, Halcion, or St John’s Wort. Use with caution if you have heart, liver, or kidney problems; diabetes; hemophilia; or if you are pregnant, plan to become pregnant, or are using hormonal birth control. Do not breastfeed.
Side effects: Most serious: heart rhythm changes, kidney or gallbladder problems, worsening liver problems, severe skin rash, diabetes or worsening diabetes, increased bleeding with hemophilia, changes in body fat or immune system
Other: nausea, yellowing of the skin or whites of the eyes