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Combination Drugs



Generic names: emtricitabine, rilpivirine, and tenofovir disoproxil fumarate


Gilead Sciences

What it does:
Helps prevent replication of HIV

Traditional dosage:
One tablet (200 mg of emtricitabine, 25 mg of rilpivirine, and 300 mg of tenofovir disoproxil fumarate), once daily, with a meal. Rilpivirine is an NNRTI, the other components NRTIs. Complera is for those who are new to antiretroviral drugs and have viral loads of 100,000 copies/ml or less.; or as a replacement regimen for individuals with a viral load of 50 copies/ml or less and no resistance to any components.

Drug interactions, precautions, & recommendations:Do not take with medicines that contain lamivudine (Epivir, Epivir-HBV, Epzicom, Combivir, Trizivir), other antiretroviral medications, antiseizure or antituberculosis drugs, proton pump inhibitors (Kapidex, Dexilant), adefovir (Hespera), St John’s Wort, or more than one dose of dexamethasone. Use caution with antacids, antifungal medications, H2-receptor antagonists, antibiotics, or methadone. If taken with Harvoni, you should be monitored.


Side effects:
Most serious: buildup of lactic acid in blood, severe liver problems, kidney damage, hepatitis B flare-up, depression, bone thinning, changes in immune system

Other: insomnia, headache, rashes, diarrhea, nausea, fatigue, dizziness, depression, abnormal dreams, vomiting, stomach or other pain, weight gain

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