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Combination Drugs



Generic name: darunavir and cobicistat



Traditional dosage: One tablet (800 mg of darunavir and 150 mg of cobicistat), once daily with food. Darunavir (Prezista) is a protease inhibitor and cobicistat (Tybost) a boosting agent.

Drug interactions, precautions, and recommendations:

Do not take with Eliquis, Pradaxa, Xarelto, Trileptal, Aptiom, Vfend, Priftin, dexamethasone, Olysio, Afinator, Serevent, Sustiva, Atripla, Intelence, Viramune, Stendra, Vitekta, Stribild, other protease inhibitors, Uroxatral, Propulsid, Propulsid Quicksolv, Multaq, D.H.E.45, Migranal, Cafergot, Ergomar, Ergostat, Medihaler, Migergot, Wigraine, Wigrettes, Methergine, Altoprev, Advicor, Mevacor, Latuda, Versed, Orap, Ranexa, Rifadin, Rifater, Rifamate, Rimactane, Revatio (when used for pulmonary arterial hypertension), Simcor, Vytorin, Zocor, St John’s Wort, or Halcion. Use with caution with Viagra, Revatio, Levitra, Staxyn, Cialis, Adcirca, Lipitor, Crestor, Pravachol, Seroquel, Coartem, or Riamet. Colchicine Colcrys, Mitigare contraindicated in those with liver or kidney problems. Use with caution if you have liver or kidney problems, or if you are pregnant, breastfeeding, or plan to become pregnant or breastfeed. 

Side effects:
Most serious: liver problems, severe or life-threatening skin rashes or reactions, high blood sugar, diabetes or worsening diabetes, increased bleeding with hemophilia, changes in body fat or immune system, new or worsening kidney problems (when taken with certain other medicines) 
other: diarrhea, nausea, rash, headache, abdominal pain, vomiting

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