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Generic name: sofosbuvir



What it does:
Treats chronic hepatitis C infection

One 400 mg tablet, once daily, in combination with ribivarin (Copegus, Rebetol, and others); with some types of hep C virus, peginterferon alfa (Pegasys) and ribavirin should both be used.

Drug interactions, precautions, & recommendations:Do not take with Cordarone, Aptivus, Olysio, Tegretol, Dilantin, Tileptal, Mycobutin, Rifadin, Priftin, St. John’s Wort, or drugs containing phenobarbital. Warnings and precautions of other direct acting hep C antivirals also apply in Sovaldi combination treatment; avoid other sofosbuvir-containing medications like Harvoni. When taken along with ribavirin or peginterferon, all of their associated warnings and contraindications apply. Do not take if you or partner are pregnant or plan to be, as birth defects or fetal death can result (when taken with ribavirin).

The Federal Drug Administration issued the following label warning to be added to all hepatitis C (HCV) direct-acting antivirals (DAAs): Risk of hepatitis B virus (HBV) reactivation in patients connected with HCV and HBV has been reported, in some cases resulting in fulminant hepatitis, hepatic failure, and death.

Side effects:
Most serious: serious symptomatic bradycardia when coadministered with cordarone, risk of HBV reactivation, fetal damage (when taken with ribavirin)
Other: fatigue, headache, nausea, insomnia, anemia

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