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Protease Inhibitors



Generic name: lopinavir and ritonavir



What it does:
Helps prevent replication of HIV

Traditional dosage:
800 mg, typically four tablets, once daily; or 400 mg, typically two tablets, twice daily. Swallow tablets whole; do not chew, break, or crush. An oral solution is available: it should be taken with food.

Drug interactions, precautions, & recommendations:
Do not take with Halcion, midazolam oral syrup, certain steroids, Incivek, Orap, Mevacor, Zocor, Rimactane, Rifadin, Rifater, Rifamate, Revatio (when used to treat pulmonary arterial hypertension), Stendra, Uroxatral, Victrelis, Xarelto, St. John’s Wort, dihydroergotamine (D.H.E. 45 and others), ergonovine (Ergotrate), methylergonovine (Methergine), or ergot-containing medicines, including ergotamine (Cafergot and others). Use with caution with Viagra, Cialis, Levitra, Adcirca, Tasigna, Sprycel, Lipitor, Crestor, Atripla, Crixivan, Sustiva, Viramune, Lexiva, Viracept, Viramune, Viread, Videx, Selzentry, Dilantin, Tegretol, Mycobutin, Flonase, Serevent, Advair, Colcrys, Tracleer, Duragesic, Ionsys, Fentora, Deltasone, Depakote, Lamictal, Seroquel, drugs containing budesonide, methadone, birth control pills, or contraceptive patches containing estrogen.

Side effects:
Most serious: changes in heart rhythm, immune system, or body fat; severe liver problems; pancreatitis; new or worsened diabetes; elevated triglyceride or cholesterol levels

Other: diarrhea, nausea, stomach pain, vomiting, weakness, headache

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