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Combination Drugs

Viekira Pak

Viekira Pak

Generic names: Ombitasvir, paritaprevir, and ritonavir tablets packaged with dasabuvir tablets

Viekira-pak

Maker:
AbbVie

What it does:
Treats chronic hepatitis C

Traditional dosage:
Two ombitasvir, paritaprevir, ritonavir 12.5/75/50 mg tablets once daily (in the morning) and one dasabuvir 250 mg tablet twice daily (morning and evening) with food, for 12 weeks. For patients with HCV genotype 1a and cirrhosis, ribivarin should be added. (Viekira Pak combines a NS5A inhibitor, a NS3/4A protease inhibitor, and a non-nucleoside NS5B polymerase inhibitor.)


Drug interactions, precautions, & recommendations:
Do not take with Uroxatral, Carbatrol, Epitol, Equetro, Tegretol, Sustiva, Atripla, Cafergot, Complera, Kaletra, Migergot, Ergomar, Ergostat, Edurant, Medihaler, Wigraine, Wigrettes, D.H.E. 45, Migranal, Ergotrate, Methergine, ethinyl estradiol-containing medicines, Lopid, Advicor, Altoprev, Mevacor, oral midazolam, Norvir-boosted Prezista, Sustiva, Dilantin, Phenytek, Luminal, Orap, Zocor, Vytorin, Simcor, Viagra, Cialis, St. John’s Wort, Halcion, Rifadin, Rifamate, Rifater, Rimactane, or Revatio when taken for pulmonary artery hypertension. Do not take if you have liver cirrhosis or have had a severe skin rash after taking ritonavir (Norvir). Use with caution if you have other liver problems or have had a liver transplant and take the medicines Prograf, Gengraf, Neoral, or Sandimmune. If taken with ribavirin (brand names Copegus, Rebetol), all ribavirin warnings and contraindications apply.

The Federal Drug Administration issued the following label warning to be added to all hepatitis C (HCV) direct-acting antivirals (DAAs): Risk of hepatitis B virus (HBV) reactivation in patients connected with HCV and HBV has been reported, in some cases resulting in fulminant hepatitis, hepatic failure, and death.

Side effects:
Most serious: liver damage or liver failure, hypersensitivity
Other: nausea, itching, sleep problems

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Ryan is the Digital Director of The Advocate Channel, and a graduate of NYU Tisch's Department of Dramatic Writing. She is also a member of GALECA, the LGBTQ+ society of entertainment critics. While her specialties are television writing and comedy, Ryan is a young member of the LGBTQ+ community passionate about politics and advocating for all.

Ryan is the Digital Director of The Advocate Channel, and a graduate of NYU Tisch's Department of Dramatic Writing. She is also a member of GALECA, the LGBTQ+ society of entertainment critics. While her specialties are television writing and comedy, Ryan is a young member of the LGBTQ+ community passionate about politics and advocating for all.