Traditional dosage: One 25 mg tablet, once daily, with a meal. For those who haven’t previously taken antiretroviral drugs and have a viral load of 100,000 copies per milliliter of blood or less. It is always taken with other antiretrovirals.
Drug interactions, precautions, & recommendations: Do not take with other NNRTIs; antiseizure drugs (Luminal, Tegretol, Trileptal, Dilantin); antituberculosis medicines (Rifadin, Rimactane, Priftin); proton pump inhibitors (Nexium, Vimovo, Prevacid, Prilosec, Protonix, Aciphex); more than one dose of dexamethasone; or St. John’s Wort. Use caution with antifungals (Sporanox, Diflucan, Nizoral, Noxavil); antibiotics (Mycobutin, Biaxin, and Ketek); methadone. Take H2 blockers (Tagamet, Pepcid, Zantac) at least 12 hours before or four hours after Edurant. Antacids containing aluminum, magnesium hydroxide, or calcium carbonate should only be administered either at least 2 hours before, or at least 4 hours after taking Edurant.
Side effects: Most serious: depression or mood changes, including suicidal thoughts; changes in body fat or immune system, severe skin rash and allergic reactions, and liver problems. Other: insomnia, headache, rash