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Generic name: daclatasvir



What it does:
Treats chronic hepatitis C

Traditional dosage:
One 60 mg tablet taken orally, once daily in combination with sofosbuvir (Sovaldi) with or without ribavirin (Rebetol, Copegus, Virazole, Ribasphere). Also available in 30 mg and 90 mg doses.

Drug interactions, precautions, & recommendations:
Do not take with amiodarone, anticonvulsants (phenytoin, carbamazepine), antimycobacterials (rifampin), and St. John’s wort. Use caution with atorvastatin, fluvastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin. Dosage adjustments may been necessary when taken with protease inhibitors (atazanavir, ritonavirb, indinavir, nelfinavir, saquinavir), cobicistat-containing antiretroviral regimens, NNRTIs (efavirenzb, etravirine, nevirapine), clarithromycin, itraconazole, ketoconazole, nefazodone, posaconazole, telithromycin, voriconazole, bosentan, dexamethasone, modafinil, nafcillin, rifapentine, and digoxin.

The Federal Drug Administration issued the following label warning to be added to all hepatitis C (HCV) direct-acting antivirals (DAAs): Risk of hepatitis B virus (HBV) reactivation in patients connected with HCV and HBV has been reported, in some cases resulting in fulminant hepatitis, hepatic failure, and death.

Side effects:
Most serious: symptomatic bradycardia (in patients taking Solvaldi, Harvoni, or amiodarone: Cordarone, Nexterone, Pacerone)
Other: headache, fatigue

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