Cytovene-IV, Vitrasert

Maker:
Roche Laboratories (Cytovene-IV), Pharmaforce (generic); Bausch and Lomb (Vitrasert)

What it does:
Treats the eye infection cytomegalovirus retinitis in transplant recipients and people with weakened immune systems, such as those with HIV

Traditional dosage:
Vitrasert, surgically implanted in the eye, consists of a 4.5-mg pellet of ganciclovir coated with polymers. For Cytovene-IV, dosages vary but should not exceed 6 mg per kg of body weight

Drug interactions, precautions, & recommendations:
Do not take with blood dyscra-sia-causing medications, bone marrow depressants, radiation therapy, nephrotoxic medications, or Retrovir. Dosage may need adjustment if you have kidney problems or take Videx or Videx EC. Use caution if you take anti-HIV medications containing zidovudine or didanosine.

Side effects:
Most serious: blood disorders, black or tarry stools, cough, sore throat, fever or chills, pain, painful urination, seeing flashes or sparks of light, floating spots, or a partial veil across vision, unusual bleeding, and unusual tiredness or weakness Other: abdominal pain, changes in behavior, diarrhea, fever, headache, increased sweating, loss of appetite, vomiting, weight loss