What it does: Treats chronic hepatitis C genotype 1 infection
Dosage: Two 375-mg tablets, three times daily, with food, in combination with ribivarin (marketed under brand names Copegus, Rebetol, and others) and peginterferon alfa (PegIntron or Pegasys)
Drug interactions, precautions, & recommendations: Do not take if you are pregnant or your partner is, or if you or your partner plan to become pregnant, as birth defects or fetal death can result. Do not take if taking HIV drug Kaletra, or Norvir combined with Lexiva or Prezista. Do not take with Mycobutin, Rifadin, Uroxatral, Revatio, Adcirca, Orap, Halcion or similar sedatives, Saint-John’s-wort, ergot derivatives, Lipitor or similar drugs. Use with caution if taking Norvir combined with Reyatas. Use with caution with Biaxin or similar antibacterial drugs, Coumadin, certain antidepressants, certain antifungal drugs, calcium channel blockers, certain drugs to treat irregular heartbeat.
Side effects: Most serious: severe and potentially fatal skin reactions such as Stevens-Johnson syndrome; if mild to moderate rash develops, monitor its progression, and stop treatment if it becomes severe. Other: mild to moderate rash, fatigue, anemia, nausea, vomiting, diarrhea, hemorrhoids